Original Article
Investigation of the predictive effect of hematologic indices in patients with intracerebral hemorrhage
View article page
Umut Ogün MutlucanORCID, Okkeş ZortukORCID
Cite
Mutlucan UO, Zortuk O. Investigation of the predictive effect of hematologic indices in patients with intracerebral hemorrhage. J Med Dent Invest. 2025;6:e250189. https://doi.org/10.5577/jomdi.e250189
- eISSN
- 2822-6453
- Submitted
- 6 February 2025
- Revised
- 26 February 2025
- Accepted
- 10 March 2025
- Published
- 28 March 2025
- Pages
- e250189
Abstract
Aim: This study investigated the role of systemic inflammatory markers in predicting mortality among intracerebral hemorrhage (ICH) patients. ICH is a severe stroke subtype with high mortality and disability rates.
Methods: Researchers analyzed data from patients who underwent surgery, including decompressive craniectomy, between 2015 and 2023. The study examined demographic data, comorbidities, observation periods, mortality rates, hemogram, and biochemistry parameters. Patients were divided into survivor (n=1205) and non-survivor (n=440) groups.
Results: Results showed non-survivors had lower hemoglobin levels and significantly higher C-reactive protein (CRP) levels compared to survivors. Inflammatory indices like the Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and Platelet-to-Lymphocyte Ratio (PLR) were also elevated in the non-survivor group. Cut-off values were determined for predicting outcomes. For example, the SII cut-off was 1793.62 (65,4% sensitivity, 58,9% specificity), and the SIRI cut-off was 4.81 (63,4% sensitivity, 58% specificity).
Conclusion: The study concluded that elevated white blood cell counts, SIRI, SII, and CRP levels are associated with increased mortality risk in ICH patients.
How to cite this article
Mutlucan UO, Zortuk Ö. Investigation of the predictive effect of hematologic indices in patients with intracerebral hemorrhage. J Med Dent Invest 2025;6:e250189.
Keywords
License
© 2025 The Author(s). Published by Journal of Medical and Dental Investigations.