Review Article
Non-fluoride systems for enamel remineralization: Types and mechanisms
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Betül KargülORCID, Nur Kodaman DokumacıgilORCID, Ayşe Nur Parlakyıldız GökçeORCID
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Kargül B, Kodaman Dokumacıgil N, Parlakyıldız Gökçe AN. Non-fluoride systems for enamel remineralization: Types and mechanisms. J Med Dent Invest. 2025;6(S1):e250074. https://doi.org/10.5577/jomdi.e250074
- eISSN
- 2822-6453
- Submitted
- 30 October 2025
- Revised
- 28 November 2025
- Accepted
- 14 December 2025
- Published
- 30 December 2025
- Pages
- e250074
Abstract
Dental caries is a significant global public health issue, despite advancements in oral hygiene practices and the emergence of new protective substances. Although it is a progressive chronic condition, can be prevented and remineralized at an early stages without the formation of cavities. Minimally invasive dentistry emphasizes the importance of preventing strategies for remineralization of White spot lesions. New approaches are being developed to promote deeper lesion remineralization, minimize the risks associated with high fluoride levels, and ensure long-term carries control. Non-fluoride remineralization can be classified into two categories: those that enhance the efficacy of fluoride and biomimetic systems that imitate enamel regeneration. The aim of this brief paper is to review the some commonly used non-fluoride remineralization systems and mechanisms, challenges, and evidence underpinning some of the technological advances in enamel remineralization.
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© 2025 The Author(s). Published by Journal of Medical and Dental Investigations.